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KMID : 1145520150010010015
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Journal of Radiopharmaceuticals and Molecular Probes
2015 Volume.1 No. 1 p.15 ~ p.22
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Strain-promoted alkyne-azide cycloaddition for PET molecular imaging study
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Jeong Hyeon-Jin
Kim Dong-Wook
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Abstract
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18F-labeling reaction of bioactive molecule via click chemistry is widely used to produce 18F-labeled radiotracer in the field of radiopharmaceutical science and molecular imaging. In particular, bioorthogonal strain-promoted alkyne-azide cycloaddition (SPAAC) reaction has received much attention as an alternative ligation method for radiolabeling bioactive molecules such as peptides, DNA, proteins as well as nanoparticles. Moreover, SPAAC based pretargeting method could provide tumor images successfully on positron emission tomography system using nanoparticle such as mesoporous silica nanoparticles.
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KEYWORD
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Bioorthogonal reaction, 18F-labeling, Radiotracer, Positron emission tomography, Copper-free click chemistry, Pretargeting
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